Skip to main content

Evidence to Improve Care

Fecal Microbiota Therapy for Clostridium difficile Infection


Ontario Health Technology Advisory Committee Recommendation

  • The Ontario Health Technology Advisory Committee recommends publicly funding fecal microbiota therapy for patients with recurrent Clostridium difficile infection

Read the full OHTAC Recommendation report



Clostridium difficile, often called "C. difficile" or "C. diff," is a bacterium that commonly causes inflammation of the colon and diarrhea. Risk factors for infection include antibiotic use, inflammatory bowel disease and increasing age. As many as 20% to 30% of patients who are diagnosed with C. difficile get the infection again. In some cases, C. difficile infections are fatal.


Health Quality Ontario Reviews Fecal Microbiota Therapy

Transplanting microbes from the digestive system of a healthy person is a simple way to get a better mix of microbes into a person infected with C. difficile. Fecal microbiota therapy, also known as a stool transplant or a fecal transplant, is the process of transplanting fecal bacteria from a healthy individual into a patient with C. difficile. Compared with using antibiotics, fecal microbiota therapy is effective and appears to represent good value for money for treating recurrent C. difficile infections.


Fecal Microbiota Therapy for Clostridium difficile Infection: A Health Technology Assessment (PDF)
July 2016


Use of this site, and the interpretation of the information contained here, is subject to important terms and conditions. Use of this site and information except in accordance with these terms and conditions is expressly prohibited.


The Ministry of Health and Long-Term Care endorses this recommendation.

The Ministry of Health and Long-Term Care has provided the following response: The Ministry agrees with this recommendation and encourages hospitals to take-up this innovative, effective, safe, and cost-saving procedure for appropriate patients. The Ministry provides public funding to Local Health Integration Networks (LHINs) and hospitals to ensure appropriate resources for procedures such as these.



Let’s make our health system healthier

Join Our Patient, Family and Public Advisors Program

Patients, families and the public are central to improving health quality.


Man smiling

Sign up for our newsletter

Are you passionate about quality health care for all Ontarians? Stay in-the-know about our newest programs, reports and news.

Health Quality Connect - Health Quality Ontario's newsletter - on an iPad and a cell phone