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Evidence to Improve Care

Placental Growth Factor (PlGF)–Based Biomarker Testing to Help Diagnose Pre-eclampsia in People With Suspected Pre-eclampsia

Final Recommendation

  • Ontario Health, based on guidance from the Ontario Health Technology Advisory Committee, recommends publicly funding placental growth factor (PlGF)–based biomarker testing as an adjunct to standard clinical assessment to help diagnose pre-eclampsia in pregnant people between 20 weeks and 36 weeks plus 6 days’ gestation with suspected pre-eclampsia.

Read the final recommendation report


Pre-eclampsia is a potentially serious condition that affects up to 1 in 20 pregnant people, most often after 20 weeks of pregnancy. Diagnosing pre-eclampsia can be difficult because symptoms and signs differ from person to person. Assessment begins during routine pregnancy appointments, when blood pressure is measured and risk factors for pre-eclampsia are checked. Blood tests have been developed to measure placental growth factor (PlGF), a protein that indicates the function of the placenta. The tests are used along with standard clinical assessment.

This health technology assessment looked at how effective and cost-effective PlGF-based biomarker testing is to help diagnose pre-eclampsia. It also looked at the budget impact of publicly funding PlGF-based biomarker testing and at the experiences, preferences, and values of people with confirmed or suspected pre-eclampsia.

Read the full health technology assessment report for more information.

Placental Growth Factor (PlGF)–Based Biomarker Testing to Help Diagnose Pre-eclampsia in People With Suspected Pre-eclampsia: A Health Technology Assessment
May 2023

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The Ministry of Health is currently reviewing this recommendation.

The Ministry of Health has provided the following response: The Ministry has a standardized process in place to review health technology assessments and funding recommendations. This takes into consideration Ministry priorities, implementation options, the need for consultation with impacted stakeholders, and funding considerations.



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