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Evidence to Improve Care

Opioid Prescribing for Chronic Pain

Care for People 15 Years of Age and Older

Click below to see a list of brief quality statements and scroll down for more information.


Quality standards are sets of concise statements designed to help health care professionals easily and quickly know what care to provide, based on the best evidence.

See below for the quality statements and click for more detail.

Quality Statement 1: Comprehensive Assessment
People with chronic pain receive a comprehensive assessment, including consideration of their functional status and social determinants of health.

Quality Statement 2: Setting Goals for Pain Management and Function
People with chronic pain set goals for pain management and functional improvement in partnership with their health care professionals. These goals are evaluated regularly.

Quality Statement 3: First-Line Treatment With Non-opioid Therapies
People with chronic pain receive an individualized and multidisciplinary approach to their care. They are offered non-opioid pharmacotherapy and nonpharmacological therapies as first-line treatment.

Quality Statement 4: Shared Decision-Making and Information on the Potential Benefits and Harms of Opioids for Chronic Pain
People with chronic pain, and their families and caregivers receive information about the potential benefits and harms of opioid therapy for chronic pain at the time of both prescribing and dispensing so that they can participate in shared decision-making.

Quality Statement 5: Initiating a Trial of Opioids for Chronic Pain
People with chronic pain begin a trial of opioid therapy only after other multimodal therapies have been tried without adequate improvement in pain and function, and they either have no contraindications to opioid therapy or have discussed any relative contraindications with their health care professional.

If opioids are initiated, the trial starts at the lowest effective dose, preferably below 50 mg morphine equivalents per day. Titrating over time to a dose of less than 90 mg morphine equivalents per day may be warranted in selected cases in which people are willing to accept a higher risk of harm for an improved pain relief.

Quality Statement 6: Co-prescribing Opioids and Benzodiazepines
People with chronic pain are not prescribed opioids and benzodiazepines at the same time whenever possible.

Quality Statement 7: Opioid Use Disorder
People prescribed opioids for chronic pain who are subsequently diagnosed with opioid use disorder have access to opioid agonist therapy.

Quality Statement 8: Prescription Monitoring Systems
Health care professionals who prescribe or dispense opioids have access to a real-time prescription monitoring system at the point of care. Prescription history is checked when opioids are prescribed and dispensed and every 3 to 6 months during long-term use, or more frequently if there are concerns regarding duplicate prescriptions, potentially harmful medication interactions, or diversion.

Quality Statement 9: Tapering and Discontinuation
All people with chronic pain on long-term opioid therapy, especially those taking 90 mg morphine equivalents or more per day, are periodically offered a trial of tapering to a lower dose or tapering to discontinuation.

Quality Statement 10: Health Care Professional Education
Health care professionals have the knowledge and skills to appropriately assess and treat chronic pain using a multidisciplinary, multimodal approach; appropriately prescribe, monitor, taper, and discontinue opioids; and recognize and treat opioid use disorder.

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Prescription Monitoring Systems

Health care professionals who prescribe or dispense opioids have access to a real-time prescription monitoring system at the point of care. Prescription history is checked when opioids are prescribed and dispensed and every 3 to 6 months during long-term use, or more frequently if there are concerns regarding duplicate prescriptions, potentially harmful medication interactions, or diversion.


Prescription monitoring systems allow health care professionals to identify patterns of opioid and other monitored drug prescribing and to reduce the potential for opioid diversion and polypharmacy. Before prescribing or dispensing an opioid, clinicians should check the prescription history of a person with chronic pain to determine whether they are receiving doses or combinations of controlled substances that are associated with an increased risk of overdose and death, including the co-prescribing of benzodiazepines or other sedatives. A person’s prescription history should be reviewed at the initiation of opioid therapy, if the dose is increased, and every 3 to 6 months for long-term stable doses. A person’s prescription history should be checked more frequently if there are concerns regarding the potential for substance use disorder, overdose, diversion, indeterminate pain disorder, or prescriptions being obtained from more than one prescriber.

For Patients

To make sure you get the safest, most effective treatment, your health care professional and pharmacist will check your prescription history before prescribing or giving you opioids. They do this to see if you have recently been given opioids or other medications that are dangerous to take with opioids.


For Clinicians

Use a prescription monitoring system at the point of care to check your patients’ prescription history when opioids are prescribed, dispensed, and every 3 to 6 months during long-term use. Check more frequently if you have concerns regarding the potential for substance use disorder, overdose, diversion, indeterminate pain disorder, or prescriptions being obtained from more than one prescriber.


For Health Services

Ensure that opioid prescribers and pharmacists have access to a real-time prescription monitoring system at the point of care.

Process Indicators

Percentage of people with chronic pain prescribed an opioid whose prescription history was reviewed at the time an opioid was prescribed

  • Denominator: total number of people with chronic pain who were prescribed an opioid and did not have an opioid prescription in the previous 6 months
  • Numerator: number of people in the denominator whose prescription history was reviewed at the time an opioid was prescribed
  • Data source: local data collection

Percentage of people with chronic pain prescribed an opioid whose prescription history was assessed at least every 6 months

  • Denominator: total number of people with chronic pain who have been on opioid therapy for at least 6 months
  • Numerator: number of people in the denominator whose prescription history was assessed at least every 6 months
  • Data source: local data collection

Structural Indicator

Availability of a prescription monitoring system to provide health care professionals who prescribe or dispense opioids with real-time prescription information at the point of care

  • Data source: provincial/regional data collection
Prescription monitoring system

A prescription monitoring system is an electronic database that collects information on controlled prescription drugs prescribed by health care professionals and dispensed by pharmacies. In Ontario, the Narcotics Monitoring System (NMS) is the central database available to enable reviews of monitored drug prescribing and dispensing activities and to alert prescribers and pharmacists to potential instances of polypharmacy and double-doctoring.

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