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Evidence to Improve Care

4

Treatment After Initial Diagnosis

People with major depression have timely access to either antidepressant medication or evidence-based psychotherapy, based on their preference. People with severe or persistent depression are offered a combination of both treatments.


Both antidepressant medications and evidence-based psychotherapies (such as cognitive behavioural therapy or interpersonal therapy) can be effective treatments for major depression. Combining antidepressants and psychotherapy may be effective for people with severe or treatment-resistant major depression.

For Patients

You should have a choice of psychotherapy or antidepressant drugs. If your depression doesn’t get better, you should be offered a combination of the two treatments.


For Clinicians

Offer people with major depression antidepressants or evidence-based psychotherapy (such as cognitive behavioural therapy or interpersonal psychotherapy). Offer a combination of the two treatments to people with severe or persistent major depression who have tried antidepressants or psychotherapy without an adequate response.


For Health Services

Ensure pharmacotherapy and evidence-based psychotherapies are available and accessible in a timely manner for all people with major depression.

Process Indicator

Percentage of people with severe major depression who receive a combination of medications and psychotherapy within 7 days of their assessment

  • Denominator: total number of people with severe major depression who have been assessed
  • Numerator: number of people in the denominator who receive medications and psychotherapy within 7 days of their assessment
  • Data source: local data collection

Percentage of people with mild to moderate major depression who receive medications or psychotherapy within 4 weeks of their assessment

  • Denominator: total number of people with mild to moderate major depression
  • Numerator: number of people in the denominator who receive medications or psychotherapy within 4 weeks of their assessment
  • Data source: local data collection

Structural Indicator

Availability of evidence-based psychotherapy

  • Data source: local data collection
Timely access
  • For severe depression: within 7 days
  • For mild to moderate depression: within 4 weeks

Evidence-based psychotherapy

This includes cognitive behavioural therapy and interpersonal psychotherapy (see below). Other psychotherapies that may be effective include behavioural activation therapy, short-term dynamic psychotherapy, and mindfulness-based cognitive therapy.


Cognitive behavioural therapy and interpersonal therapy

Cognitive behavioural therapy and interpersonal therapy for major depression should each be:

  • Delivered on a one-to-one or group basis
  • Delivered over 16 to 20 sessions over 3 to 4 months
  • Delivered by an appropriately trained therapist in accordance with a treatment manual

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